一、个人简介

 刘瑞娟，女，汉族，1986年9月出生，山东省菏泽人，讲师职称。2019年6月毕业于兰州大学药学院药物化学生物学专业，获理学博士学位。同年来院任教，从事运动人体科学专业教学科研工作。

二、研究方向运动生理学

三、主要成果主持西北师范大学2020年度青年教师科研能力提升计划项目一项。近年来在Molecular Pharmaceutics，Chemical Communications，Toxicology and Applied Pharmacology等国内外刊物上发表学术论文10余篇。

四、近五年代表性论文

[1] Ruijuan Liu, Danfeng Shi, Junmin Zhang, Xinming Li, Xiao Han, Xiaojun Yao, Jianguo Fang*. Xanthatin promotes apoptosis via inhibiting thioredoxin reductase and eliciting oxidative stress[J]. Molecular Pharmaceutics, 2018, 15(8): 3285-3296.

[2] Ruijuan Liu, Danfeng Shi, Junmin Zhang, Xinming Li, Xiao Han, Xiaojun Yao*, Jianguo Fang*. Virtual screening-guided discovery of thioredoxin reductase inhibitors[J]. Toxicology and Applied Pharmacology, 2019, 370: 106-116.

[3] Wang Baojun, Liu Ruijuan, Fang Jianguo, Wang Yawen, Peng Yu*. A water-soluble dual-site fluorescent probe for the rapid detection of cysteine with high sensitivity and specificity[J]. Chemical Communications, 2019, 55(78): 11762-11765.

[4]Du Wei, Liu Ruijuan, Fang Jianguo, Gao Hong, Wang Yawen, Peng Yu*. Two chemodosimeters for fluorescence recognition of biothiols in aqueous solution and their bioimaging application[J]. Tetrahedron, 2019, 75(36): 130477.

[5]Junmin Zhang, Xinming Li, Xiao Han, Ruijuan Liu, Jianguo Fang*. Targeting the thioredoxin system for cancer therapy[J]. Trends in pharmacological sciences, 2017, 38(9): 794-808.  

[6] Junmin Zhang, Baoxin Zhang, Xinming Li, Xiao Han, Ruijuan Liu, Jianguo Fang*. Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: An update[J]. Medicinal research reviews, 2019, 39(1): 5-39.  

[7] Liangwei Zhang, Shoujiao Peng, Jinyu Sun, Ruijuan Liu, Jianguo Fang*. A ratiometric fluorescent probe of methionine sulfoxide reductase with an improved response rate. Chemical Communications, 2019, 55(10), 1502-1505.  

五、近五年科研项目

[1]黄腐酚基Nrf2通路对骨骼肌运动氧化应激损伤的保护机制探究，（NWNU-SKQN2020-38），2020年度青年教师科研能力提升计划项目，主持。

[2]硫氧还蛋白还原酶小分子模拟物的设计、合成及神经保护功效研究（21778028），2018年国家自然基金项目，参与。